Substitution of formaldehyde as a tissue fixative

Formaldehyde is an organic compound used as a tissue fixative for microscopy and histology. In this case study, formaldehyde was substituted by a product containing: ethyl alcohol, isopropyl alcohol and acetic acid under the commercial name Fixall-his. The compound was chosen for its relatively low level of health risks and the successful experience of substitution in French hospitals. The fact that substitution had already occurred in other hospitals is a significant driver in convincing social players of its validity as a substitute of Formaldehyde as a fixative of tissue samples.